Product ID:DEPO-MEDROL STERILE AQUEOUS SUSPENSION
MSDS Date:06/30/1994
FSC:6505
NIIN:01-156-2174
MSDS Number: BWFCF

UPJOHN COMPANY, THE

7171 PORTAGE ROAD
KALAMAZOO, MI 49001-0199
US

Emergency Phone: 616-323-5122 24 HOURS

Info Phone: 30 PM)

Preparer: HEALTH & SAFETY REG AFFRS

Cage: 93703

PHARMACIA & UPJOHN

KALAMAZOO, MI 49001-0199 US

Telephone: 616-833-5122/616-833-7555

Cage: 93703

WATER

CAS: 7732-18-5

RTECS: ZC0110000

Fraction By Weight: 88-94%

POLYETHYLENE GLYCOL 3350

Fraction By Weight: 3%

METHYL PREDISOLONE ACETATE

CAS: 53-36-1

RTECS: TU4154050

Fraction By Weight: 2-8%

SODIUM CHLORIDE

CAS: 7647-14-5

RTECS: VZ4725000

Fraction By Weight: <1%

LD50 LC50 Mixture:ORAL LD50 (RAT) IS >10 G/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EYES:NON-IRRITATING.SKIN:MILDLY
IRRITATING.INGEST:NOT REPORTED.INHAL:NOT REPORTED.SYSTEMIC
EFFECTS:AFFECTS,CVS,KIDNEY,SKELETAL MUSCLES,NERVIOUS AND IMMUNE
SYSTEM.CHRONIC OVEREXPOSURE MAY PRODUCE PITUI TARY-ADRENAL
SUPRESSION(CUSHING'S SYNDROME-REDISTRIBUTION OF BODY FAT("MOON
FACE")),OSTEOPORISIS,CATARACTS (SEE SUPPL)
Explanation of Carcinogenicity:THERE ARE NO INGREDIENTS ABOVE 0.1%
WHICH ARE IDENTIFIED AS CARCINOGENS BY NTP,IARC OR OSHA.
Effects of Overexposure:CHRONIC:MUSCLE WEAKNESS,FATIGUE,HIGH BLOOD
PRESSURE,HYPERGLYCEMIA,GLYCOSURIA,ACNE,MENSTRUAL DISORDERS,PEPTIC
ULCERS.
Medical Cond Aggravated by Exposure:OVEREXPOSURE TO CORTICOSTEROIDS MAY
INCREASE SUSCEPTIBILITY TO INFECTION(EG.LATENT
TUBERCULOSIS,SECONDARY EYE INFECTIONS(FUNGAL AND VIRAL) AND MAY
MASK SIGNS OF INFECTION.(SEE SUPPL)

First Aid:SKIN:REMOVE CONTAMINATED CLOTHING;WASH WITH SOAP AND
WATER.EYES:FLUSH WITH WATER FOR 15 MINUTES.INHAL:REMOVE TO FRESH
AIR.GIVE OXYGEN OR ARTIFICIAL RESPIRATION IF NEEDED.INGEST:DO NOT
INDUCE VOMITING. GET PROMPT QUALIFIED MEDICAL ATTENTION.

Flash Point:NONE
Extinguishing Media:WATER,DRY CHEMICAL,CARBON DIOXIDE.
Fire Fighting Procedures:USE A SELF-CONTAINED BREATHING APPARATUS AND
FULL PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:THE FINELY DISPURSED DUST FROM THIS
PRODUCT IS A FIRE OR EXPLOSION HAZARD IN THE PRESENCE OF SOURCES OF
IGNITION.

Spill Release Procedures:REMOVE SOURCES OF IGNITION.VENTILATE AREA.USE
PROPER PROTECTIVE AND RESPIRATORY EQUIPMENT.SWEEP OR VACUUM(USING A
HEPA FILTER AND EXPLOSION-PROOF EQUIPMENT);DO NOT CREATE DUST;PLACE
IN A DRY CONTAINER FOR DISPOSAL.PREVENT CONTAMINATION OF
WATERWAYS.
Neutralizing Agent:NOT APPLICABLE.

Handling and Storage Precautions:STORE AT ROOM TEMPERTURE(59-86F).KEEP
CONTAINER CLOSED WHEN NOT IN USE.KEEP AWAY FROM CHILDREN.KEEP AWAY
FROM LIGHT.
Other Precautions:SUPPLIMENTAL DATA(CONT'D):NDC 00909-0274-01;
3073-01/02; 0280-02/32/03/33; 3475-01/02; 0306-02/10.

Respiratory Protection:NOT NEEDED IN NORMAL SERVICE.
Ventilation:USE LOCAL EXHAUST.
Protective Gloves:RUBBER.
Eye Protection:SAFETY GLASSES WITH SIDESHIELDS.
Other Protective Equipment:PROVIDE A LOCAL EYE WASH STATION.
Work Hygienic Practices:EXECISE GOOD LABORATORY PRACTICES.WASH HANDS
AFTER USE AND BEFORE EATING.
Supplemental Safety and Health
HLTH HAZ(CONT'D):INCREASED SUSCEPTIBILTY TO INFECTION,SUPRESSION OF
INFLAMMATORY RESPONSE,CATARACTS,POSSIBLE DAMAGE TO THE OPTIC
NERVE,ELEVATED BLOOD PRESSURE,SALT AND WATER RETENTION,INCREASED
POTASS IUM AND CALCIUM EXCRETION.MED COND AGGR(CONT'D):RECENT
IMMUNIZATION,HYPERTHYROIDISM AND CIRRHOSIS(SEE OTHER PRECAUTIONS)

HCC:N1
Solubility in Water:COMPLETE
Appearance and Odor:LIQUID.COLOR AND ODOR NOT REPORTED.

Stability Indicator/Materials to Avoid:YES
MANUFACTURER STATES NONE.
Stability Condition to Avoid:MANUFACTURER STATES NONE.
Hazardous Decomposition Products:CARBON DIOXIDE,CARBON MONOXIDE.

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH FEDERAL,STATE AND
LOCAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.